Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury.

ABSTRACT: Cardiovascular disease is the leading cause of mortality worldwide. While reperfusion therapy is vital for patient survival post-heart attack, it also causes further tissue injury, known as myocardial ischemia/reperfusion (I/R) injury in clinical practice. Exploring ways to attenuate I/R injury is of clinical interest for improving post-ischemic recovery. A platelet-inspired nanocell (PINC) that incorporates both prostaglandin E2 (PGE₂)-modified platelet membrane and cardiac stromal cell-secreted factors to target the heart after I/R injury is introduced. By taking advantage of the natural infarct-homing ability of platelet membrane and the overexpression of PGE₂ receptors (EPs) in the pathological cardiac microenvironment after I/R injury, the PINCs can achieve targe

SUBMITTER: Su T 

PROVIDER: S-EPMC7111457 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature