PiRNAs Regulated by Mitochondria Variation Linked With Reproduction and Aging in Caenorhabditis elegans.

ABSTRACT: In Caenorhabditis elegans, the binding of Piwi protein to a non-coding RNA form, called piRNA, has been found to be important to both reproductive and aging processes. As the biosynthesis of piRNA is modulated by mitochondrial function, it is likely that the interaction between mitochondrial function and piRNA expression plays an unknown, yet important, role in reproductive and aging processes because both processes are known to be affected by declines in mitochondrial quality and activity. While the relationship between reproduction and longevity is not characterized in full, the optimality theory of aging and the disposable soma theory suggest that a trade-off between energy and resources is needed for reproductive and aging maintenance. In this study, the influence of mitochondri

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC7111505 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature