An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis.

ABSTRACT: Thousands of epigenomic data sets have been generated in the past decade, but it is difficult for researchers to effectively use all the data relevant to their projects. Systematic integrative analysis can help meet this need, and the VISION project was established for validated systematic integration of epigenomic data in hematopoiesis. Here, we systematically integrated extensive data recording epigenetic features and transcriptomes from many sources, including individual laboratories and consortia, to produce a comprehensive view of the regulatory landscape of differentiating hematopoietic cell types in mouse. By using IDEAS as our integrative and discriminative epigenome annotation system, we identified and assigned

SUBMITTER: Xiang G 

PROVIDER: S-EPMC7111515 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature