Gene expression networks in the Drosophila Genetic Reference Panel.

ABSTRACT: A major challenge in modern biology is to understand how naturally occurring variation in DNA sequences affects complex organismal traits through networks of intermediate molecular phenotypes. This question is best addressed in a genetic mapping population in which all molecular polymorphisms are known and for which molecular endophenotypes and complex traits are assessed on the same genotypes. Here, we performed deep RNA sequencing of 200 Drosophila Genetic Reference Panel inbred lines with complete genome sequences and for which phenotypes of many quantitative traits have been evaluated. We mapped expression quantitative trait loci for annotated genes, novel transcribed regions, transposable elements, and microbial species. We identified host variants that affect expression of tra

SUBMITTER: Everett LJ 

PROVIDER: S-EPMC7111517 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature