Increased indoleamine 2,3-dioxygenase activity and expression in prostate cancer following targeted immunotherapy.

ABSTRACT:

Background

We previously found that PD-L1 expression is increased on tumor cells following vaccination treatments that lead to increased tumor-specific T cells that secrete IFNγ. Indoleamine 2,3-dioxygenase (IDO) is another IFNγ inducible gene that has potent immunosuppressive effects. There have been reports of IDO expression in prostate cancer; however, it is unknown whether IDO expression might similarly increase in prostate tumors following T-cell-based immunotherapy.

Methods

Blood samples from normal male blood donors (n = 12) and patients with different stages of prostate cancer (n = 89), including patients with metastatic, castration-resistant prostate cancer treated with a DNA vaccine and/or pembrolizumab, were evaluated for IDO activity by kynurenine and tryptophan

SUBMITTER: Zahm CD 

PROVIDER: S-EPMC7111534 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature