Reliability and Utility of Manual and Automated Estimates of Total Intracranial Volume.

ABSTRACT:

Objectives

Total intracranial volume (TICV) is an important control variable in brain-behavior research, yet its calculation has challenges. Manual TICV (Manual) is labor intensive, and automatic methods vary in reliability. To identify an accurate automatic approach we assessed the reliability of two FreeSurfer TICV metrics (eTIV and Brainmask) relative to manual TICV. We then assessed how these metrics alter associations between left entorhinal cortex (ERC) volume and story retention.

Methods

Forty individuals with Parkinson's disease (PD) and 40 non-PD peers completed a brain MRI and memory testing. Manual metrics were compared to FreeSurfer's Brainmask (a skull strip mask with total volume of gray, white, and most cerebrospinal fluid) and eTIV (calculated using the trans

SUBMITTER: Crowley SJ 

PROVIDER: S-EPMC7111586 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature