Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation.

ABSTRACT: Type I interferons (IFNs) are essential to the clearance of viral diseases, however, a clear distinction between genes upregulated by direct virus-cell interactions and genes upregulated by secondary IFN production has not been made. Here, we investigated differential gene regulation in ferrets upon subcutaneous administration of IFN-α2b and during SARS-CoV infection. In vivo experiments revealed that IFN-α2b causes STAT1 phosphorylation and upregulation of abundant IFN response genes (IRGs), chemokine receptors, and other genes that participate in phagocytosis and leukocyte transendothelial migration. During infection with SARS-CoV not only a variety of IRGs were upregulated, but also a significantly broader range of genes involved in cell migration and inflammation. This work allowed dis

SUBMITTER: Danesh A 

PROVIDER: S-EPMC7111932 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature