A systematic pipeline for classifying bacterial operons reveals the evolutionary landscape of biofilm machineries.

ABSTRACT: In bacteria functionally related genes comprising metabolic pathways and protein complexes are frequently encoded in operons and are widely conserved across phylogenetically diverse species. The evolution of these operon-encoded processes is affected by diverse mechanisms such as gene duplication, loss, rearrangement, and horizontal transfer. These mechanisms can result in functional diversification, increasing the potential evolution of novel biological pathways, and enabling pre-existing pathways to adapt to the requirements of particular environments. Despite the fundamental importance that these mechanisms play in bacterial environmental adaptation, a systematic approach for studying the evolution of operon organization is lacking. Herein, we present a novel method to study the evoluti

SUBMITTER: Bundalovic-Torma C 

PROVIDER: S-EPMC7112194 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature