Swimming motility of a gut bacterial symbiont promotes resistance to intestinal expulsion and enhances inflammation.

ABSTRACT: Some of the densest microbial ecosystems in nature thrive within the intestines of humans and other animals. To protect mucosal tissues and maintain immune tolerance, animal hosts actively sequester bacteria within the intestinal lumen. In response, numerous bacterial pathogens and pathobionts have evolved strategies to subvert spatial restrictions, thereby undermining immune homeostasis. However, in many cases, it is unclear how escaping host spatial control benefits gut bacteria and how changes in intestinal biogeography are connected to inflammation. A better understanding of these processes could uncover new targets for treating microbiome-mediated inflammatory diseases. To this end, we investigated the spatial organization and dynamics of bacterial populations within the intestine usi

SUBMITTER: Wiles TJ 

PROVIDER: S-EPMC7112236 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature