The Egyptian Rousette Genome Reveals Unexpected Features of Bat Antiviral Immunity.

ABSTRACT: Bats harbor many viruses asymptomatically, including several notorious for causing extreme virulence in humans. To identify differences between antiviral mechanisms in humans and bats, we sequenced, assembled, and analyzed the genome of Rousettus aegyptiacus, a natural reservoir of Marburg virus and the only known reservoir for any filovirus. We found an expanded and diversified KLRC/KLRD family of natural killer cell receptors, MHC class I genes, and type I interferons, which dramatically differ from their functional counterparts in other mammals. Such concerted evolution of key components of bat immunity is strongly suggestive of novel modes of antiviral defense. An evaluation of the theoretical function of these genes suggests that an inhibitory immune state may exist in bats. Based on

SUBMITTER: Pavlovich SS 

PROVIDER: S-EPMC7112298 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature