Short- and long-term efficacy of prednisolone for first acute rhinovirus-induced wheezing episode.

ABSTRACT:

Background

Rhinovirus-induced wheezing is an important risk factor for recurrent wheezing. There are no randomized controlled trials on the effect of systemic corticosteroids in patients with this disease.

Objective

We sought to study the short- and long-term effects of prednisolone treatment of the first acute, moderate-to-severe, rhinovirus-induced wheezing episode in young children.

Methods

After confirming rhinovirus from nasopharyngeal aspirate by using PCR, 79 children with a first wheezing episode at age 3 to 23 months were randomized to receive oral prednisolone (first dose of 2 mg/kg, followed by 2 mg/kg/d in 2 divided doses for 3 days) or placebo. The trial was double blind throughout the 12-month follow-up. The primary outcomes were long term: new physician

SUBMITTER: Jartti T 

PROVIDER: S-EPMC7112325 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature