Treatment with anti-C5a antibody improves the outcome of H7N9 virus infection in African green monkeys.

ABSTRACT:

Background

Patients infected with influenza A(H7N9) virus present with acute lung injury (ALI) that is due to severe pneumonia and systemic inflammation. It is often fatal because there are few effective treatment options. Complement activation has been implicated in the pathogenesis of virus-induced lung injury; therefore, we investigated the effect of targeted complement inhibition on ALI induced by H7N9 virus infection.

Methods

A novel neutralizing specific antihuman C5a antibody (IFX-1) was used. This antibody blocked the ability of C5a to induce granulocytes to express CD11b while not affecting the ability of C5b to form the membrane attack complex. African green monkeys were inoculated with H7N9 virus and treated intravenously with IFX-1.

Results

The virus infec

SUBMITTER: Sun S 

PROVIDER: S-EPMC7112341 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature