Identification of a Primary Renal AT₂ Receptor Defect in Spontaneously Hypertensive Rats.

ABSTRACT:

Rationale

Previous studies identified a defect in Ang III (angiotensin III [des-aspartyl¹-angiotensin II])-elicited AT₂R (Ang type-2 receptor)-mediated natriuresis in renal proximal tubule cells of spontaneously hypertensive rats (SHR).

Objective

This study aimed to delineate in prehypertensive SHR kidneys the receptor or postreceptor defect causing impaired AT₂R signaling and renal sodium (Na⁺) retention by utilizing the selective AT₂R agonist compound-21 (C-21).

Methods and results

Female 4-week-old Wistar Kyoto and SHR rats were studied after 24-hour systemic AT₁R (Ang II type-1 receptor) blockade. Left kidneys received 30-minute renal interstitial infusions of vehicle followed by C-21 (20, 40, and 6

SUBMITTER: Kemp BA 

PROVIDER: S-EPMC7112539 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature