Specificity, kinetics and longevity of antibody responses to avian influenza A(H7N9) virus infection in humans.

ABSTRACT:

Objectives

The long-term dynamics of antibody responses in patients with influenza A(H7N9) virus infection are not well understood.

Methods

We conducted a longitudinal serological follow-up study in patients who were hospitalized with A(H7N9) virus infection, during 2013-2018. A(H7N9) virus-specific antibody responses were assessed by hemagglutination inhibition (HAI) and neutralization (NT) assays. A random intercept model was used to fit a curve to HAI antibody responses over time. HAI antibody responses were compared by clinical severity.

Results

Of 67 patients with A(H7N9) virus infection, HAI antibody titers reached 40 on average 11 days after illness onset and peaked at a titer of 290 after three months, and average titers of ≥80 and ≥40 were present until 11 mo

SUBMITTER: Chen J 

PROVIDER: S-EPMC7112568 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature