Bone Mineral Density After Transitioning From Denosumab to Alendronate.

ABSTRACT: There are few studies on patients transitioning from denosumab to bisphosphonates. To investigate patient characteristics and changes in bone mineral density (BMD) after transitioning from denosumab to alendronate. Randomized, open-label, 2-year crossover Denosumab Adherence Preference Satisfaction (DAPS) study (NCT00518531). 25 study centers in the US and Canada. Treatment-naïve postmenopausal women with BMD T-scores from -2.0 to -4.0. This post hoc analysis evaluated women randomized to subcutaneous denosumab 60 mg every 6 months in year 1 followed by once-weekly oral alendronate 70 mg in year 2. A 3% BMD threshold identified participants who lost, maintained, or gained BMD in year 2 on alendronate. Of 126 participants randomized to denosumab, 115 (91%) transitioned to alendronate in yea

SUBMITTER: Kendler D 

PROVIDER: S-EPMC7112973 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature