Circ-IGF1R inhibits cell invasion and migration in non-small cell lung cancer.

ABSTRACT:

Background

Circular RNA (circRNA) is a novel molecular marker and target candidate that is closely associated with tumor invasion and migration. The mechanism of action of hsa_circ_0005035 (circ-IGF1R) in non-small cell lung cancer remains unclear. In this study, we aimed to study the mechanism of action of circ-IGF1R in lung cancer.

Methods

We screened circ-IGF1R, one of the most notable differential expressions, from the Gene Expression Omnibus database, GSE104854, for further research. The expression level of circ-IGF1R was examined using quantitative reverse transcription-polymerase chain reaction (qRT-PCR) in five different lung cancer cell lines and 50 pairs of lung cancer and adjacent tissues. Wound-healing and Transwell assays were used for verifying the biological f

SUBMITTER: Xu Z 

PROVIDER: S-EPMC7113055 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature