Rheumatoid Arthritis Morning Stiffness Is Associated With Synovial Fibrin and Neutrophils.

ABSTRACT:

Objective

Morning stiffness is a hallmark symptom of rheumatoid arthritis (RA), but its etiology is poorly understood. This study was undertaken to determine whether any histologic features of synovium are associated with this symptom.

Methods

Data on patient-reported morning stiffness duration and severity, and Disease Activity Score in 28 joints (DAS28) were collected from 176 patients with RA undergoing arthroplasty. Synovium was scored for 10 histopathologic features: synovial lining hyperplasia, lymphocytes, plasma cells, Russell bodies, binucleate plasma cells, fibrin, synovial giant cells, detritus, neutrophils, and mucin. Fibrinolysis of clots seeded with various cell types was measured in turbidimetric lysis assays.

Results

Stiffness severity and morning stif

SUBMITTER: Orange DE 

PROVIDER: S-EPMC7113097 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature