Immune profile and immunosurveillance in treatment-naive and neoadjuvantly treated esophageal adenocarcinoma.

ABSTRACT: The outcome in esophageal adenocarcinoma (EAC) is still poor with only 20% of patients in Western populations surviving for more than 5 years. Almost nothing is known about the precise composition of immune cells and their gene expression profiles in primary resected EACs and also nothing compared to neoadjuvant treated EACs. This study analyzes and compares immune profiles of primary resected and neoadjuvant treated esophageal adenocarcinoma and unravels possible targets for immunotherapy. We analyzed 47 EAC in total considering a set of 30 primary treatment-naive EACs and 17 neoadjuvant pretreated (12 × CROSS, 5 × FLOT) using the Nanostring's panel-based gene expression platform including 770 genes being important in malignant tumors and their immune micromileu. Most of the significantly

SUBMITTER: Wagener-Ryczek S 

PROVIDER: S-EPMC7113210 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature