Identifying Biomarkers in Lymph Node Metastases of Esophageal Adenocarcinoma for Tumor-Targeted Imaging.

ABSTRACT:

Introduction

Tumor-targeted imaging is a promising technique for the detection of lymph node metastases (LNM) and primary tumors. It remains unclear which biomarker is the most suitable target to distinguish malignant from healthy tissue in esophageal adenocarcinoma (EAC).

Objective

We performed an immunohistochemistry study to identify viable tumor markers for tumor-targeted imaging of EAC.

Methods

We used samples from 72 patients with EAC to determine the immunohistochemical expression of ten potential tumor biomarkers for EAC (carbonic anhydrase IX [CA-IX], carcinoembryonic antigen [CEA], hepatic growth factor receptor, epidermal growth factor receptor, epithelial membrane antigen [EMA], epithelial cell adhesion molecule [EpCAM], human epidermal growth factor recep

SUBMITTER: de Gouw DJJM 

PROVIDER: S-EPMC7113228 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature