Tortuosity-powered microfluidic device for assessment of thrombosis and antithrombotic therapy in whole blood.

ABSTRACT: Accurate assessment of blood thrombosis and antithrombotic therapy is essential for the management of patients in a variety of clinical conditions, including surgery and on extracorporeal life support. However, current monitoring devices do not measure the effects of hemodynamic forces that contribute significantly to coagulation, platelet function and fibrin formation. This limits the extent to which current assays can predict clotting status in patients. Here, we demonstrate that a biomimetic microfluidic device consisting stenosed and tortuous arteriolar vessels would analyze blood clotting under flow, while requiring a small blood volume. When the device is connected to an inline pressure sensor a clotting time analysis is applied, allowing for the accurate measurement of coagulation,

SUBMITTER: Luna DJ 

PROVIDER: S-EPMC7113244 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature