Human Chorionic Gonadotropin modulates CXCL10 Expression through Histone Methylation in human decidua.

ABSTRACT: The process of implantation, trophoblast invasion and placentation demand continuous adaptation and modifications between the trophoblast (embryonic) and the decidua (maternal). Within the decidua, the maternal immune system undergoes continued changes, as the pregnancy progress, in terms of the cell population, phenotype and production of immune factors, cytokines and chemokines. Human chorionic gonadotropin (hCG) is one of the earliest hormones produced by the blastocyst and has potent immune modulatory effects, especially in relation to T cells. We hypothesized that trophoblast-derived hCG modulates the immune population present at the maternal fetal interface by modifying the cytokine profile produced by the stromal/decidual cells. Using in vitro models from decidual samples we demonst

SUBMITTER: Silasi M 

PROVIDER: S-EPMC7113245 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature