The molecular etiology of deafness and auditory performance in the postlingually deafened cochlear implantees.

ABSTRACT: Recent advances in molecular genetic testing (MGT) have improved identification of genetic aetiology of candidates for cochlear implantation (CI). However, whether genetic information increases CI outcome predictability in post-lingual deafness remains unclear. Therefore, we evaluated the outcomes of CI with respect to genetic aetiology and clinical predictors by comparing the data of study subjects; those with an identified genetic aetiology (GD group), and those without identifiable variants (GUD group). First, we identified the genetic aetiology in 21 of 40 subjects and also observed genetic etiologic heterogeneity. The GD group demonstrated significantly greater improvement in speech perception scores over a 1-year period than did the GUD group. Further, inverse correlation between dea

SUBMITTER: Lee SY 

PROVIDER: S-EPMC7113281 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature