Cardiotrophin-1 Deficiency Abrogates Atherosclerosis Progression.

ABSTRACT: Cardiotrophin-1 (CT-1) is associated with cardiovascular (CV) diseases. We investigated the effect of CT-1 deficiency in the development and progression of atherosclerosis in double knockout Apoe^-/-ct-1^-/- mice. Apoe^-/- C57Bl/6 or Apoe^-/-ct-1^-/- C57Bl/6 mice were fed a normal chow diet (NCD) or a high-cholesterol diet (HCD). After sacrifice, serum triglycerides, total cholesterol, low-density lipoprotein cholesterol (LDL-C), free fatty acids and systemic paracrine factors were measured. Intraplaque lipid and collagen content were quantified in the aortic sections. Immune cell populations in spleen, lymph nodes and aorta were analysis by flow cytometry. Apoe^-/-ct-1^-/- mice in accelerated atherosclerosis exhibited a

SUBMITTER: Miteva K 

PROVIDER: S-EPMC7113288 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature