Major surgery induces acute changes in measured DNA methylation associated with immune response pathways.

ABSTRACT: Surgery is an invasive procedure evoking acute inflammatory and immune responses that can influence risk for postoperative complications including cognitive dysfunction and delirium. Although the specific mechanisms driving these responses have not been well-characterized, they are hypothesized to involve the epigenetic regulation of gene expression. We quantified genome-wide levels of DNA methylation in peripheral blood mononuclear cells (PBMCs) longitudinally collected from a cohort of elderly patients undergoing major surgery, comparing samples collected at baseline to those collected immediately post-operatively and at discharge from hospital. We identified acute changes in measured DNA methylation at sites annotated to immune system genes, paralleling changes in serum-levels of marker

SUBMITTER: Sadahiro R 

PROVIDER: S-EPMC7113299 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature