Computing Skin Cutaneous Melanoma Outcome From the HLA-Alleles and Clinical Characteristics.

ABSTRACT: Human leukocyte antigen (HLA) are essential components of the immune system that stimulate immune cells to provide protection and defense against cancer. Thousands of HLA alleles have been reported in the literature, but only a specific set of HLA alleles are present in an individual. The capability of the immune system to recognize cancer-associated mutations depends on the presence of a particular set of alleles, which elicit an immune response to fight against cancer. Therefore, the occurrence of specific HLA alleles affects the survival outcome of cancer patients. In the current study, prediction models were developed, using 401 cutaneous melanoma patients, to predict the overall survival (OS) of patients using their clinical data and HLA alleles. We observed that the presence of certa

SUBMITTER: Dhall A 

PROVIDER: S-EPMC7113398 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature