Identification of microRNAs in skeletal muscle associated with lung cancer cachexia.

ABSTRACT:

Background

Cachexia, highly prevalent in patients with non-small cell lung cancer (NSCLC), impairs quality of life and is associated with reduced tolerance and responsiveness to cancer therapy and decreased survival. MicroRNAs (miRNAs) are small non-coding RNAs that play a central role in post-transcriptional gene regulation. Changes in intramuscular levels of miRNAs have been implicated in muscle wasting conditions. Here, we aimed to identify miRNAs that are differentially expressed in skeletal muscle of cachectic lung cancer patients to increase our understanding of cachexia and to allow us to probe their potential as therapeutic targets.

Methods

A total of 754 unique miRNAs were profiled and analysed in vastus lateralis muscle biopsies of newly diagnosed treatment-naïve N

SUBMITTER: van de Worp WRPH 

PROVIDER: S-EPMC7113505 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature