Celastrol inhibits dengue virus replication via up-regulating type I interferon and downstream interferon-stimulated responses.

ABSTRACT:

Ethnopharmacological relevance and aim of the study

Tripterygium wilfordii (lei gong teng; Thunder of God Vine), a member of the Celastraceae family, is a medicinal plant used to treat a range of illnesses. Celastrol is a quinone methide triterpene and the most abundant bioactive constituent isolated from the root extracts of T. wilfordii. Previous studies have shown that celastrol exhibits antiviral activity against HIV and SARS-CoV. To date, no investigations of the anti-DENV activity of celastrol have been reported. This work aimed to investigate the anti-DENV effect and possible mechanism of celastrol in vitro and in vivo.

Methods

A four-serotype DENV infection system was performed to determine the anti-DENV effect of celastrol by detecting DENV RNA replication and prote

SUBMITTER: Yu JS 

PROVIDER: S-EPMC7113783 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature