Interaction between the Antimalarial Drug Dispiro-Tetraoxanes and Human Serum Albumin: A Combined Study with Spectroscopic Methods and Computational Studies.

ABSTRACT: Dispiro-tetraoxanes, a class of fully synthetic peroxides which can be used as an antiplasmodial remedy for multiple drug-resistant strains of Plasmodium falciparum, were selected for the interaction study with human serum albumin (HSA). The insight into the interaction of the two chemically synthesized, most potent antimalarial tetraoxane analogues (TO1 and TO2) and HSA has been scrutinized using distinct spectroscopic techniques such as. UV-visible absorption, fluorescence, time-resolved fluorescence, and circular dichroism (CD). Fluorescence quenching experiments divulged the static mode of quenching and binding constants obtained (∼10⁴) indicated the moderate affinity of the analogues to HSA. CD confirmed the conformational changes in the serum albumin upon interactio

SUBMITTER: Yadav P 

PROVIDER: S-EPMC7114135 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature