Rasputin a decade on and more promiscuous than ever? A review of G3BPs.

ABSTRACT: Ras-GTPase-activating protein (SH3 domain)-binding proteins (G3BPs, also known as Rasputin) are a family of RNA binding proteins that regulate gene expression in response to environmental stresses by controlling mRNA stability and translation. G3BPs appear to facilitate this activity through their role in stress granules for which they are considered a core component, however, it should be noted that not all stress granules contain G3BPs and this appears to be contextual depending on the environmental stress and the cell type. Although the role of G3BPs in stress granules appears to be one of its major roles, data also strongly suggests that they interact with mRNAs outside of stress granules to regulate gene expression. G3BPs have been implicated in several diseases including cancer progr

SUBMITTER: Alam U 

PROVIDER: S-EPMC7114234 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature