Valosin-containing protein (VCP/p97) plays a role in the replication of West Nile virus.

ABSTRACT: Valosin-containing protein (VCP) is classified as a member of the type II AAA⁺ ATPase protein family. VCP functions in several cellular processes, including protein degradation, membrane fusion, vesicular trafficking and disassembly of stress granules. Moreover, VCP is considered to play a role in the replication of several viruses, albeit through different mechanisms. In the present study, we have investigated the role of VCP in West Nile virus (WNV) infection. Endogenous VCP expression was inhibited using either VCP inhibitors or by siRNA knockdown. It could be shown that the inhibition of endogenous VCP expression significantly inhibited WNV infection. The entry assay revealed that silencing of endogenous VCP caused a significant reduction in the expression levels of WNV-RNA

SUBMITTER: Phongphaew W 

PROVIDER: S-EPMC7114552 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature