A hallmark of phospholamban functional divergence is located in the N-terminal phosphorylation domain.

ABSTRACT: Sarcoplasmic reticulum Ca²⁺ pump (SERCA) is a critical component of the Ca²⁺ transport machinery in myocytes. There is clear evidence for regulation of SERCA activity by PLB, whose activity is modulated by phosphorylation of its N-terminal domain (residues 1-25), but there is less clear evidence for the role of this domain in PLB's functional divergence. It is widely accepted that only sarcolipin (SLN), a protein that shares substantial homology with PLB, uncouples SERCA Ca²⁺ transport from ATP hydrolysis by inducing a structural change of its energy-transduction domain; yet, experimental evidence shows that the transmembrane domain of PLB (residues 26-52, PLB_26-52) partially uncouples SERCA in vitro. These apparently conflicting mechanism

SUBMITTER: Fernandez-de Gortari E 

PROVIDER: S-EPMC7114604 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature