High-intensity interval training in allogeneic adoptive T-cell immunotherapy - a big HIT?

ABSTRACT:

Background

Adoptive transfer of virus-specific T cells (VSTs) represents a prophylactic and curative approach for opportunistic viral infections and reactivations after transplantation. However, inadequate frequencies of circulating memory VSTs in the T-cell donor's peripheral blood often result in insufficient enrichment efficiency and purity of the final T-cell product, limiting the effectiveness of this approach.

Methods

This pilot study was designed as a cross-over trial and compared the effect of a single bout (30 min) of high-intensity interval training (HIT) with that of 30 min of continuous exercise (CONT) on the frequency and function of circulating donor VSTs. To this end, we used established immunoassays to examine the donors' cellular immune status, in particular

SUBMITTER: Heinemann NC 

PROVIDER: S-EPMC7114817 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature