Gut microbiota from persons with attention-deficit/hyperactivity disorder affects the brain in mice.

ABSTRACT:

Background

The impact of the gut microbiota on host physiology and behavior has been relatively well established. Whether changes in microbial composition affect brain structure and function is largely elusive, however. This is important as altered brain structure and function have been implicated in various neurodevelopmental disorders, like attention-deficit/hyperactivity disorder (ADHD). We hypothesized that gut microbiota of persons with and without ADHD, when transplanted into mice, would differentially modify brain function and/or structure. We investigated this by colonizing young, male, germ-free C57BL/6JOlaHsd mice with microbiota from individuals with and without ADHD. We generated and analyzed microbiome data, assessed brain structure and function by magnetic resonance i

SUBMITTER: Tengeler AC 

PROVIDER: S-EPMC7114819 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature