Research progress in the biological activities of 3,4,5-trimethoxycinnamic acid (TMCA) derivatives.

ABSTRACT: TMCA (3,4,5-trimethoxycinnamic acid) ester and amide are privileged structural scaffolds in drug discovery which are widely distributed in natural products and consequently produced diverse therapeutically relevant pharmacological functions. Owing to the potential of TMCA ester and amide analogues as therapeutic agents, researches on chemical syntheses and modifications have been carried out to drug-like candidates with broad range of medicinal properties such as antitumor, antiviral, CNS (central nervous system) agents, antimicrobial, anti-inflammatory and hematologic agents for a long time. At the same time, SAR (structure-activity relationship) studies have draw greater attention among medicinal chemists, and many of the lead compounds were derived for various disease targets. However,

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC7115657 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature