A brainwide atlas of synapses across the mouse life span.
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ABSTRACT:
SUBMITTER: Cizeron M
PROVIDER: S-EPMC7115813 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
A brainwide atlas of synapses across the mouse life span.
Cizeron Mélissa M Qiu Zhen Z Koniaris Babis B Gokhale Ragini R Komiyama Noboru H NH Fransén Erik E Grant Seth G N SGN
Science (New York, N.Y.) 20200611 6501
Synapses connect neurons together to form the circuits of the brain, and their molecular composition controls innate and learned behavior. We analyzed the molecular and morphological diversity of 5 billion excitatory synapses at single-synapse resolution across the mouse brain from birth to old age. A continuum of changes alters synapse composition in all brain regions across the life span. Expansion in synapse diversity produces differentiation of brain regions until early adulthood, and compos ...[more]
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