International prognostic scoring system for mastocytosis (IPSM): a retrospective cohort study.

ABSTRACT:

Background

The WHO classification separates mastocytosis into distinct variants, but prognostication remains a clinical challenge. The aim of this study was to improve prognostication for patients with mastocytosis.

Methods

We analysed data of the registry of the European Competence Network on Mastocytosis including 1639 patients (age 17-90 years) diagnosed with mastocytosis according to WHO criteria between Jan 12, 1978, and March 16, 2017. Univariate and multivariate analyses with Cox regression were applied to identify prognostic variables predicting survival outcomes and to establish a prognostic score. We validated this International Prognostic Scoring System in Mastocytosis (IPSM) with data of 462 patients (age 17-79 years) from the Spanish network Red Española de Mast

SUBMITTER: Sperr WR 

PROVIDER: S-EPMC7115823 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature