Waveform changes with the evolution of beta bursts in the human subthalamic nucleus.

ABSTRACT:

Objective

Phasic bursts of beta band synchronisation have been linked to motor impairment in Parkinson's disease (PD). However, little is known about what terminates bursts.

Methods

We used the Hilbert-Huang transform to investigate beta bursts in the local field potential recorded from the subthalamic nucleus in nine patients with PD on and off levodopa.

Results

The sharpness of the beta waveform extrema fell as burst amplitude dropped. Conversely, an index of phase slips between waveform extrema, and the power of concurrent theta activity increased as burst amplitude fell. Theta activity was also increased on levodopa when beta bursts were attenuated. These phenomena were associated with reduction in coupling between beta phase and high gamma activity amplitude. We

SUBMITTER: Yeh CH 

PROVIDER: S-EPMC7115847 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature