No persistent attenuation of fear memories in humans: A registered replication of the reactivation-extinction effect.

ABSTRACT: It has been proposed that memory retrieval can destabilize consolidated memories, after which they need to be reconsolidated in order to be retained. The presentation of relevant information during memory reconsolidation could then result in the modification of a destabilized memory trace, by allowing the memory trace to be updated before being reconsolidated. In line with this idea, Schiller et al. (2010) have demonstrated that memory retrieval shortly before extinction training can prevent the later recovery of conditioned fear responding that is observed after regular extinction training. Those findings have been the subject of considerable controversy, due in part to theoretical reasons but also due to a number of failures to obtain similar results in conceptual replication attempts. H

SUBMITTER: Chalkia A 

PROVIDER: S-EPMC7115861 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature