Peptides from allergenic lipocalins bind to formyl peptide receptor 3 in human dendritic cells to mediate T_H2 immunity.

ABSTRACT:

Background

How T_H2-mediated allergic immune responses are induced is still under investigation.

Objective

In an in vitro system we compared the effect of lipocalin allergens and nonallergenic homologues on human monocyte-derived dendritic cells (DCs) to investigate how they polarize naive CD4⁺ T_H cells. Microarray data gained with these DCs showed a significant difference in expression of formyl peptide receptors (FPRs). Activation of FPR3 in human monocyte-derived DCs leads to inhibition of IL-12 production. Low concentrations of IL-12 during T-cell priming biases immune responses toward T_H2. We hypothesize that binding of allergenic lipocalins to FPR3 might be a mechanism for induction of allergic immune responses.

Methods

SUBMITTER: Klaver D 

PROVIDER: S-EPMC7115912 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature