Study Protocol - Insight 46 Cardiovascular: A Sub-study of the MRC National Survey of Health and Development.

ABSTRACT: The commonest causes of dementia are Alzheimer's disease and vascular cognitive impairment. Although these conditions have been viewed as distinct entities, there is increasing evidence that neurodegenerative and vascular pathologies interact or overlap to cause cognitive decline, and that at least in some cases individuals at risk of cognitive decline exhibit abnormal cardiovascular physiology long before emergence of disease. However, the mechanisms linking haemodynamic disturbances with cognitive impairment and the various pathologies that cause dementia are poorly understood. A sub-sample of 502 participants from the Medical Research Council National Survey of Health and Development (NSHD) have participated in the first visit of a neuroscience sub-study referred to as Insight 46, where

SUBMITTER: Mason SA 

PROVIDER: S-EPMC7116008 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature