Non-negative data-driven mapping of structural connections with application to the neonatal brain.

ABSTRACT: Mapping connections in the neonatal brain can provide insight into the crucial early stages of neurodevelopment that shape brain organisation and lay the foundations for cognition and behaviour. Diffusion MRI and tractography provide unique opportunities for such explorations, through estimation of white matter bundles and brain connectivity. Atlas-based tractography protocols, i.e. a priori defined sets of masks and logical operations in a template space, have been commonly used in the adult brain to drive such explorations. However, rapid growth and maturation of the brain during early development make it challenging to ensure correspondence and validity of such atlas-based tractography approaches in the developing brain. An alternative can be provided by data-driven methods, which do no

SUBMITTER: Thompson E 

PROVIDER: S-EPMC7116021 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature