A gammaherpesvirus licenses CD8 T cells to protect the host from pneumovirus-induced immunopathologies.

ABSTRACT: Human respiratory syncytial virus (RSV) is a pneumovirus that causes severe infections in infants worldwide. Despite intensive research, safe and effective vaccines against RSV have remained elusive. The main reason is that RSV infection of children previously immunized with formalin-inactivated-RSV vaccines has been associated with exacerbated pathology, a phenomenon called RSV vaccine-enhanced respiratory disease. In parallel, despite the high RSV prevalence, only a minor proportion of children develop severe diseases. Interestingly, variation in the immune responses against RSV or following RSV vaccination could be linked with differences of exposure to microbes during childhood. Gammaherpesviruses (γHVs), such as the Epstein-Barr virus, are persistent viruses that deeply influence the

SUBMITTER: Dourcy M 

PROVIDER: S-EPMC7116076 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature