BMP signaling protects telencephalic fate by repressing eye identity and its Cxcr4-dependent morphogenesis.

ABSTRACT: Depletion of Wnt signaling is a major requirement for the induction of the anterior prosencephalon. However, the molecular events driving the differential regionalization of this area into eye-field and telencephalon fates are still unknown. Here we show that the BMP pathway is active in the anterior neural ectoderm during late blastula to early gastrula stage in zebrafish. Bmp2b mutants and mosaic loss-of-function experiments reveal that BMP acts as a repressor of eye-field fate through inhibition of its key transcription factor Rx3, thereby protecting the future telencephalon from acquiring eye identity. This BMP-driven mechanism initiates the establishment of the telencephalon prior to the involvement of Wnt antagonists from the anterior neural border. Furthermore, we demonstrate that R

SUBMITTER: Bielen H 

PROVIDER: S-EPMC7116079 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature