Adjusting conventional FRAX estimates of fracture probability according to the recency of sentinel fractures.

ABSTRACT: The risk of a recurrent fragility fracture is particularly high immediately following the fracture. This study provides adjustments to FRAX-based fracture probabilities accounting for the site of a recent fracture.

Introduction

The recency of prior fractures affects subsequent fracture risk. The aim of this study was to quantify the effect of a recent sentinel fracture, by site, on the 10-year probability of fracture determined with FRAX.

Methods

The study used data from the Reykjavik Study fracture register that documented prospectively all fractures at all skeletal sites in a large sample of the population of Iceland. Fracture probabilities were determined after a sentinel fracture (humeral, clinical vertebral, forearm and hip fracture) from the hazards of death and fractur

SUBMITTER: Kanis JA 

PROVIDER: S-EPMC7116089 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature