Common functional networks in the mouse brain revealed by multi-centre resting-state fMRI analysis.

ABSTRACT: Preclinical applications of resting-state functional magnetic resonance imaging (rsfMRI) offer the possibility to non-invasively probe whole-brain network dynamics and to investigate the determinants of altered network signatures observed in human studies. Mouse rsfMRI has been increasingly adopted by numerous laboratories worldwide. Here we describe a multi-centre comparison of 17 mouse rsfMRI datasets via a common image processing and analysis pipeline. Despite prominent cross-laboratory differences in equipment and imaging procedures, we report the reproducible identification of several large-scale resting-state networks (RSN), including a mouse default-mode network, in the majority of datasets. A combination of factors was associated with enhanced reproducibility in functional connecti

SUBMITTER: Grandjean J 

PROVIDER: S-EPMC7116112 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature