A Versatile Biosynthetic Hydrogel Platform for Engineering of Tissue Analogues.

ABSTRACT: For creating functional tissue analogues in tissue engineering, stem cells require very specific 3D microenvironments to thrive and mature. Demanding (stem) cell types that are used nowadays can find such an environment in a heterogeneous protein mixture with the trade name Matrigel. Several variations of synthetic hydrogel platforms composed of poly(ethylene glycol) (PEG), which are spiked with peptides, have been recently developed and shown equivalence to Matrigel for stem cell differentiation. Here a clinically relevant hydrogel platform, based on PEG and gelatin, which even outperforms Matrigel when targeting 3D prevascularized bone and liver organoid tissue engineering models is presented. The hybrid hydrogel with natural and synthetic components stimulates efficient cell differentia

SUBMITTER: Klotz BJ 

PROVIDER: S-EPMC7116179 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature