Melt electrowriting onto anatomically relevant biodegradable substrates: Resurfacing a diarthrodial joint.

ABSTRACT: Three-dimensional printed hydrogel constructs with well-organized melt electrowritten (MEW) fibrereinforcing scaffolds have been demonstrated as a promising regenerative approach to treat small cartilage defects. Here, we investige how to translate the fabrication of small fibre-reinforced structures on flat surfaces to anatomically relevant structures. In particular, the accurate deposition of MEW-fibres onto curved surfaces of conductive and non-conductive regenerative biomaterials is studied. This study reveals that clinically relevant materials with low conductivities are compatible with resurfacing with organized MEW fibres. Importantly, accurate patterning on non-flat surfaces was successfully shown, provided that a constant electrical field strength and an electrical force normal to

SUBMITTER: Peiffer QC 

PROVIDER: S-EPMC7116215 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature