Acute effects of adaptive Deep Brain Stimulation in Parkinson's disease.

ABSTRACT:

Background

Beta-based adaptive Deep Brain Stimulation (aDBS) is effective in Parkinson's disease (PD), when assessed in the immediate post-implantation phase. However, the potential benefits of aDBS in patients with electrodes chronically implanted, in whom changes due to the microlesion effect have disappeared, are yet to be assessed.

Methods

To determine the acute effectiveness and side-effect profile of aDBS in PD compared to conventional continuous DBS (cDBS) and no stimulation (NoStim), years after DBS implantation, 13 PD patients undergoing battery replacement were pseudo-randomised in a crossover fashion, into three conditions (NoStim, aDBS or cDBS), with a 2-min interval between them. Patient videos were blindly evaluated using a short version of the Unified Parkinso

SUBMITTER: Pina-Fuentes D 

PROVIDER: S-EPMC7116216 | biostudies-literature | 2020 Nov - Dec

REPOSITORIES: biostudies-literature