Impact of the antibiotic-cargo from MSNs on Gram-positive and Gram-negative bacterial biofilms

ABSTRACT: Mesoporous silica nanoparticles (MSNs) are promising drug nanocarriers for infection treatment. Many investigations have focused on evaluating the capacity of MSNs to encapsulate antibiotics and release them in a controlled fashion. However, little attention has been paid to determine the antibiotic doses released from these nanosystems that are effective against biofilm during the entire release time. Herein, we report a systematic and quantitative study of the direct effect of the antibiotic-cargo released from MSNs on Gram-positive and Gram-negative bacterial biofilms. Levofloxacin (LVX), gentamicin (GM) and rifampin (RIF) were separately loaded into pure-silica and amino-modified MSNs. This accounts for the versatility of these nanosystems since they were able to load and release diffe

SUBMITTER: Aguilar-Colomer A 

PROVIDER: S-EPMC7116279 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature