Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms.

ABSTRACT: Acetaldehyde is a highly reactive, DNA-damaging metabolite that is produced upon alcohol consumption¹. Impaired detoxification of acetaldehyde is common in the Asian population, and is associated with alcohol-related cancers^1,2. Cells are protected against acetaldehyde-induced damage by DNA crosslink repair, which when impaired causes Fanconi anaemia (FA), a disease resulting in failure to produce blood cells and a predisposition to cancer^3,4. The combined inactivation of acetaldehyde detoxification and the FA pathway induces mutation, accelerates malignancies and causes the rapid attrition of blood stem cells^5-7. However, the nature of the DNA damage induced by acetaldehyde and how this is repaired remains a key question. Here we generate acetal

SUBMITTER: Hodskinson MR 

PROVIDER: S-EPMC7116288 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature